POLYMYXIN P, NEW ANTIBIOTICS OF POLYMYXIN GROUP
نویسندگان
چکیده
منابع مشابه
Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics.
Polymyxins are cationic lipopeptide antibiotics active against many species of Gram-negative bacteria. We sequenced the gene cluster for polymyxin biosynthesis from Paenibacillus polymyxa PKB1. The 40.8 kb gene cluster comprises three nonribosomal peptide synthetase-encoding genes and two ABC transporter-like genes. Disruption of a peptide synthetase gene abolished all antibiotic production, wh...
متن کاملSynergism between Sulphonamide Drugs and Antibiotics of the Polymyxin Group against Proteus Sp. in Vitro.
Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wid...
متن کاملStudies on Polymyxin: Isolation and Identification of Bacillus polymyxa and Differentiation of Polymyxin from Certain Known Antibiotics.
Polymyxin is an antibiotic substance occurring in the culture filtrates of Bacillus polymyxa. The isolated substance is unique in its specificity for gram-negative bacteria. A summary of the more important results obtained during the course of several years, including chemotherapeutic and toxicity data, has been reported (Stansly, Shepherd, and White, 1947). The present contribution is concerne...
متن کاملPolymyxin b: controlled biosynthesis.
The polymyxins form a group of closely related strongly basic cyclicpeptide antibiotics with a rather specific activity against gram-negative bacteria. The most well-known and commercially produced members are poly-myxin B and E (colistin). These two consists of polymyxin B1, B2, B3 and E1, E2, E " the single components of them differing only in the fatty acid moiety of the side chain attached ...
متن کاملFramework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus.
In the face of diminishing therapeutic options for the treatment of infections caused by multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and polymyxin B. These antibiotics became available clinically in the 1950s, when understanding of antimicrobial pharmacology and regulatory requirements for approval of drugs was substantially less than today. At the 1s...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1969
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.22.449